The pituitary gland is a kidney-bean-sized gland located at the base of your brain.
The pituitary gland is one of the most important organs of the body’s system of glands that make hormones, called the endocrine system. This gland makes several hormones, which act on nearly every part of the body. It affects many other endocrine organs, so symptoms can be gradual or sudden and dramatic.
Hypopituitarism is a rare condition in which there’s a deficiency of one, multiple or all of the hormones made by your pituitary gland. A disorder when the pituitary gland doesn’t make one or more hormones or doesn’t make enough hormones.
The symptoms of hypopituitarism usually start slowly and get worse over time, in certain conditions, the symptoms may start all of the sudden. Its symptoms also vary from person to person, depending upon which hormones are lacking. For example,
- Growth hormone (GH) deficiency can cause growth problems, especially in children.
- Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) deficiency, called gonadotropins, affects the reproductive system – that keeps the ovaries from making enough eggs and oestrogen, while in males keeps the testicles from making enough sperm and testosterone.
- Hypothyroidism – Thyroid-stimulating hormone (TSH) deficiency leads to low levels of thyroid hormones.
- Adrenocorticotropic hormone (ACTH) deficiency can cause high levels of stress as this hormone helps the adrenal glands work correctly.
- Anti-diuretic hormone (ADH) deficiency – this hormone helps the body balance its fluid levels.
- Prolactin is the hormone that tells the body when to start making breast milk. Low levels of prolactin can cause problems with making milk for breastfeeding.
Usually, its deficiency may cause.
- Poor growth and short height in children
- Severe fatigue & tiredness
- Muscle Weakness
- Bad headaches and dizziness
- Changes in vision – a tumor can press on the optic nerves, causing vision problems.
- Changes in body fat – Weight loss or gain issues
- Muscle aches
- Low blood pressure
- Confusion
- Loss of interest in activities.
- Lack of social contacts
- Lower sex drive
- Infertility issues – hard or impossible to have children.
- Delayed puberty or physical changes to body.
- Decreased facial or body hair including loss of pubic hair
- Hot flashes.
- Irregular periods or no periods.
- Lack of milk production in nursing moms.
- Erectile dysfunction – not being able to get or keep an erection.
- Mood changes.
- Dry skin.
- Sensitivity to cold or trouble staying warm.
- Recurrent or repeated infections.
- Nausea, vomiting, constipation or abdominal pain.
- Enuresis – Urinating more than usual.
- Extreme thirst.
- Imbalances in minerals & electrolytes such as sodium and potassium etc.
Possible causes and Risk factors of Hypopituitarism.
- A change in a gene – a heredity tendency – which means it is passed down in families.
- Head or brain trauma – Pressure on the pituitary gland or hypothalamus may cause its damage.
- Brain or pituitary gland tumor
- Brain surgery
- Infections or inflammation of the brain
- Radiation therapy to the brain
- Stroke
- Subarachnoid haemorrhage
- Nerve and vascular damage from unmanaged Type 1 diabetes.
- Sickle cell anaemia can cause a deficiency of pituitary hormones.
- Meningitis, or infections that can spread to the brain, such as tuberculosis or syphilis.
- Pituitary adenomas: A benign tumor on your pituitary gland.
- Hemochromatosis – a disease that causes too much iron in the liver and other tissues.
- Postpartum pituitary necrosis – Severe blood loss after childbirth can also result in pituitary damage.
- Lymphocytic hypophysitis a rare condition where lymphocytes attack your pituitary gland – cause swelling or inflammation.
- Sarcoidosis is a medical condition that causes inflammation.
- Pituitary apoplexy – an emergency condition where there is a sudden destruction of pituitary gland tissue.
- Lack of blood flow to the brain or pituitary gland, known as a stroke, or called haemorrhage.
- Certain medicines, such as narcotics, high-dose steroids or certain cancer medicines called checkpoint inhibitors.
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