“Biliary” means the bile ducts and “Cholangitis” means inflammation in your bile ducts.
Bile is a fluid made in the liver. It helps with digestion and absorbing certain vitamins. It also helps the body absorb fats and get rid of cholesterol, toxins and worn-out red blood cells.
Primary biliary cholangitis is an autoimmune liver disease that inflames and slowly destroys the bile ducts that run through your liver, making it harder for bile to flow through, that backs up the bile inside the liver and damages the tissues.
Ongoing inflammation in the liver can lead to bile duct inflammation and damage known as cholangitis.
Scar tissue gradually replaces healthy tissue, and the liver gradually loses its functionality. This is known as cirrhosis, that can eventually lead to liver failure.
Most Common early symptoms may include.
- Fatigue
- Itchy skin.
Later it can develop further signs and symptoms such as:
- Yellowing of the skin and eyes, called jaundice.
- Dry eyes and mouth.
- Pain in the upper right abdomen.
- Bones, muscles or joints pain.
- Oedema – Swollen feet and ankles.
- Ascites – Buildup of fluid in the abdomen due to liver failure.
- Fatty deposits, called xanthomas, on the skin around the eyes, eyelids or in the creases of the palms, soles, elbows or knees.
- Hyperpigmentation or liver spots – dark skin patches that is not due to exposure to sun exposure.
- Hypothyroidism – Underactive thyroid
- Unintentional weight loss.
- Fat malabsorption – When the digestive system lacks the bile it needs, it has trouble breaking down and absorbing fats. can cause:
- High blood cholesterol.
- Lipomas – Fat deposits under your skin.
- Fatty poop or Steatorrhea – Diarrhea that may include greasy stools.
- Low levels of fat-soluble vitamins A, D, E and K.
- Osteoporosis – weak and brittle bones, which can lead to fractures. (from failure to absorb fat-soluble vitamin D).
- Portal hypertension – due to obstruction caused by scar tissue in the blood vessels in the liver that run through it — high blood pressure in those veins and the veins that branch off from them.
- Enlarged liver.
- Swelling of the spleen, called splenomegaly.
- Reduced immunity – more frequent colds and infections.
- Thrombocytopenia – easy bleeding and bruising.
- Spider angiomas – red, spiderlike blood vessels under the surface of your skin.
- Swollen veins (varices) in the oesophagus and abdomen.
- Gastrointestinal bleeding.
- Occasional mental confusion (from the buildup of toxins in your blood).
Possible Causes or Risk Factors
- Possibly an autoimmune disease may be triggered by environmental and genetic factors.
- The condition mostly affects women – around 30 to 60 years old.
- Genetics or family history.
- Infections, such as a urinary tract infection.
- Smoking cigarettes, especially over long periods of time.
- Exposure to toxic chemicals.
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