The adrenal glands are part of the endocrine system and make hormones that affect almost all organs and tissue in the body.
They are two small glands that sit on top of the kidneys.
They produce 2 essential hormones: cortisol and aldosterone.
Addison’s disease, also known as primary adrenal insufficiency or hypoadrenalism, is a rare disorder of adrenal glands.
- It happens due to a damage to the adrenal glands.
- Damage to these glands results in too little cortisol and often aldosterone hormones.
- It’s also more common in women than men.
- It can affect people of any age, although it’s most common between the ages of 30 and 50 and can be life-threatening.
Seek emergency treatment if following symptoms appear:
- Reduced consciousness or delirium
- Severe abdominal pain, vomiting and diarrhoea, leading to dehydration.
- Low blood pressure
- Severe weakness
- Confusion
- Pain in the lower back or legs
Some of the main functions of adrenal glands include:
- Body’s ability to turn food into energy.
- Immune system’s inflammatory and stress response.
- The adrenal glands also make small amounts of androgens or sex hormones and cause male sexual development, libido, affect muscle mass and a general sense of well-being etc.
- While aldosterone, help balance the body’s sodium and potassium levels and to keep blood pressure in a healthy range.
Most Common signs and symptoms of this disorder may include.
- Slow progressive fatigue and weakness
- Muscle aches and pains
- Anorexia- Lack of appetite
- Increased sense of taste, smell and hearing
- Increased thirst
- Dehydration
- Ill-defined abdominal pain
- Nausea and vomiting
- Craving for salt
- Cramps
- Diarrhoea
- Unintentional weight loss
- Anxiety and depression
- Irritability & Restlessness
- Low mood
- Lack of motivation
- Trouble sleeping
- Brain fog
- Dizziness
- Decrease in axillary and pubic hair in women.
- Low blood pressure and low sugar levels even fainting.
- Reproductive problem
- Impotency
- Amenorrhea – Menstrual periods may become irregular or altogether stop.
- Skin changes – hyper pigmentation that is change in the colour of the skin such as brown or bronze darkening of neck, hands, underarms, lips, face and nipples areolas etc.
- Tanning of skin from exposure to sun
- Bluish blackish patches may appear on the mucous membranes.
- Dark freckles and occasionally white patches vitiligo may appear.
An effective medical approach is to identify and treat the causative factors!
Possible Causes and Risk factors of Addison’s disease.
- Usually, an autoimmune disorder that causes it to attack the outer layer of the adrenal gland.
- Tuberculosis
- Radiation therapy
- Fungal infection
- Congenital enzyme defects
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