Cushing syndrome or hypercortisolism is a hormonal disorder that occurs when the body produces high levels of cortisol for a prolonged period of time.
Cortisol hormone that is made in the adrenal gland and is important for various functions such as:
- Controlling blood pressure.
- Reducing inflammation.
- Helping the heart and blood vessels work correctly.
- Controlling blood sugar.
- Helping the body use food for energy.
- Regulates metabolism and
- Assist with memory formation etc.
But too much cortisol, on the other hand, can cause symptoms such as a fatty hump between the shoulders, a rounded face and pink or purple stretch marks on the skin.
Cushing syndrome also can cause high blood pressure or bone loss. Sometimes, it can cause type 2 diabetes.
Symptoms of Cushing syndrome can vary depending on the level of extra cortisol.
Common symptoms of Cushing syndrome
- Weight gain in the face and trunk although arms and legs remain thin.
- Pink or purple stretch marks on the stomach, hips, thighs, breasts and underarms.
- Thin, frail skin that bruises easily.
- Slow wound healing.
- Pimples or Acne.
Women may experience, apart from above.
- Hirsutism that is unwanted thick, dark hair on the face and other body parts.
- Irregular or skipped periods.
Particular symptoms men with Cushing syndrome
- Loss of libido or lower sex drive.
- Infertility or reduced fertility.
- Erectile dysfunction or getting proper erection.
Misc. Other symptoms
- Depression, anxiety and irritability.
- Emotions that are hard to control – mood swings
- Trouble concentrating or remembering.
- Stunted growth in children.
- Extreme tiredness.
- Muscle weakness.
- Diabetes or high blood sugar
- Increased thirst
- Increased urination,
- Increased number of infections.
- Skin affections: Thin, fragile skin that bruises easily, purple or pink stretch marks, especially on the stomach, hips, thighs, breasts, and underarms and skin pigmentation or darkening.
- Bones affections: Bone loss or weak bones which can lead to broken bones. Backaches, or breaks in the ribs or spine.
- Weight – abdominal obesity, but with thin arms and legs.
Possible causes:
Cushing syndrome is usually caused by long-term use of steroid medications, which contain synthetic cortisol.
It can also be caused by tumours in the pituitary gland or adrenal glands that produce too much cortisol.
Further Complications
- Bone loss, also called osteoporosis, which can lead to broken bones.
- Serious or multiple infections.
- Loss of muscle mass and strength.
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