Calcium is essential for the normal function of organs, cells, muscles, and nerves. It’s also important in blood clotting and bone health – but its elevated levels can cause serious problems such as weakening of bones, kidney stones, thyroid disorders. It also can affect the heart and brain. Extremely high levels of calcium can be life-threatening.
Hypercalcemia is a condition in which the calcium concentration in the blood becomes too high.
Hypercalcemia can lead to calcification, which is an abnormal buildup of calcium in various tissues or organs, where it shouldn’t be.
It can cause various health disorders, such as:
- Nephrocalcinosis: Renal calcification or kidney stones – If the urine contains too much calcium, crystals might form in the kidneys.
- Kidney failure. Over time, this condition limits the kidneys’ ability to clean the blood and get rid of extra fluid and damages the kidneys.
- Calcifications in the thyroid can be a sign of benign or malignant thyroid disease
- Pancreatitis – deposition in the pancreatic duct
- Peptic ulcer disease
- Cardiovascular disease such as the heart valves and coronary arteries etc.
- Nervous system conditions – headache, fatigue, confusion, dementia and coma.
Common Symptoms
Some people have no symptoms at all!
Others may experience mild to moderate issues.
- Renal system. Increased thirst and frequent urination.
- Pain between your back and upper abdomen on one side due to kidney stones
- Digestive system – vomiting, constipation, nausea, abdominal pain, decreased appetite etc
- Bones and muscles – bones pain, muscle weakness, twitches and cramps.
- Osteoporosis – thinning bones. It could develop if the bones keep releasing calcium into the blood, that can lead to broken bones, fractures, curving of the spinal column and loss of height.
- Brain – trouble focusing, confusion, drowsiness, fatigue, irritability even depression in severe cases.
- Heart – serious hypercalcemia can affect the heart – feelings of a fast-beating, arrhythmia, fluttering or pounding heart, as it can affect the electrical signals that control the heartbeat.
Possible Causes & Risk Factors
- Genetic factor.
- The parathyroid glands are four small glands located behind the thyroid gland in the neck.
- Overactive parathyroid glands, when parathyroid gland makes too much hormone. When the parathyroid glands work right, they release hormones that help maintain the right balance of calcium in the blood.
- Self-medication or taking too much of calcium carbonate antacids, calcium and vitamin D supplements.
- Certain conditions like hyperparathyroidism, sarcoidosis, tuberculosis, metastatic disease, and myeloma.
- Lung cancer, breast cancer, bones metastasis and some blood cancers can raise the risk of hypercalcemia.
- Sedentary lifestyle – spending a lot of time sitting or lying down can get hypercalcemia.
- Severe dehydration.
- Some medicines such as lithium and thiazide diuretics might cause more parathyroid hormone to be released.
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