PROLACTIN is a hormone produced in the pituitary gland, commonly known as the “Milk Hormone”.
The condition of having too much Prolactin is known as hyper-prolactinemia, that can effect both women and men!
Prolactin has many other functions in the body:
- Acting on the reproductive system
- Influences behaviour
- Regulates the immune system.
- Regulation of fluids (osmoregulation).
- Metabolic functions.
Normal Range of Prolactin Levels
- Women who are not pregnant is less than 25 ng/mL.
- Women who are pregnant is between 34 – 386 ng/mL.
- In men is between 2 – 18 ng/mL.
Prolactinoma is a noncancerous tumor of the pituitary gland. This tumor causes the pituitary gland to make too much of a hormone called prolactin.
Prolactin can disrupt the reproductive system (hypogonadism). The major effect of a prolactinoma is decreased levels of certain sex hormones — namely, oestrogen and testosterone.
Some of the signs and symptoms of a prolactinoma are specific to females or males.
In both females and males, prolactinoma can cause:
- Infertility
- Osteoporosis – Weak and brittle bones that break easily
- Loss of libido – low sex drive or desire in sexual activity
Pressure from enlarged tumor can cause:
- Vision problems
- Headache
- Reduction of other hormones produced by the pituitary gland
Symptoms Of Hyper-Prolactinemia specific to Females
- Amenorrhoea – Irregular – absent, missed or having no periods.
- Infrequent periods and change in menstrual flow.
- Galactorrhoea – unwanted production of milk or milky discharge from the breasts when not pregnant or breastfeeding.
- Painful intercourse
- Acne, pimples
- Hirsutism – excessive body and facial hair growth
- Premenstrual mood symptoms
- Breasts pain / tenderness
- Hot flashes
- Vaginal dryness
- Polycystic ovarian syndrome (PCOD)
- Haemorrhage / bleeding
In men the symptoms may include:
- ED – Erectile dysfunction
- Decreased body and facial hair
- Smaller or shrunk muscles – decreased muscle mass
- Enlargement of breast (gynaecomastia)
- Rarely breast milk production
- Low / zero sperm count
Possible causes and Risk factors for high prolactin levels.
- The most common cause is a benign (non-cancerous) tumour in the pituitary gland known as a prolactinoma which secretes excessive prolactin.
- Pregnancy, breastfeeding
- Infection, injury or tumour of hypothalamus (small region of the brain located near the pituitary gland)
- Hypothyroidism
- Low blood sugar levels
- Anorexia nervosa (an eating disorder in which a person has excessive weight loss and there is fear of gaining weight and becoming fat)
- Kidney disease e.g., chronic kidney failure
- Cushing’s disease (excessive release of adreno-corticotropic hormone)
- Cirrhosis of liver (scarring of liver)
- Use of certain medicines e.g. antidepressants, antipsychotics, antihypertensives, acid H2 blockers, birth control pills, opiate medicine used to relieve pain.
- Excessive use of certain herbs like fenugreek and fennel seeds
- Injuries or irritation of the chest wall
- Extreme stress or exercise.
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