Megaloblastic anaemia is a certain type of anaemia that occurs when the body produces unhealthy red blood cells that are abnormally large and underdeveloped mainly due to deficiency of vitamin B12 and folate.
When red blood cells are too large they don’t work properly and this reduces their ability to carry oxygen to various parts of the body.
Common Symptoms that develop slowly over a period and may include:
- Fatigue
- Shortness of breath
- Dizziness
- Tiredness
- Weakness in muscles
- Numbness or tingling in hands and feet
- Nausea
- Decreased appetite
- Weight loss
- Irritability
- Diarrhoea
- Smooth or tender tongue
- Pale or yellowish skin
- Irregular heartbeats
- Personality changes
- Unsteady movements
- Mental confusion or forgetfulness
Possible Causes & Risk factors
Vitamin deficiency anaemia can occur if you don’t eat enough foods containing vitamin B12 and folate, or if we have trouble absorbing or processing these vitamins.
- A deficiency in vitamin B12 and / or folic acid is the most common cause of megaloblastic anaemia.
Other causes include:
- Older age.
- Intestinal or digestive diseases like celiac disease, Crohn’s disease, ulcerative colitis and type 1 diabetes.
- Side effects of certain medicines such as anti-seizure medications, metformin and proton pump inhibitors
- Inherited conditions like congenital folate malabsorption
- Rare disorders like Imerslund-Graesbeck syndrome or Dihydrofolate reductase deficiency
- Pernicious anaemia, where the body’s immune system attacks cells in the stomach that produce a substance called intrinsic factor. Without this substance, B12 can’t be absorbed in the intestines.
- History of gastric surgeries.
- Intestinal worms
- Excessive alcohol consumption
- Pregnant women and women who are breastfeeding have an increased demand for folate, as people undergoing dialysis for kidney disease.
- Vitamin B12 is mainly found in fish, read meat, poultry, eggs and dairy – milk, some breakfast cereals and some nutritional yeast products etc.
- Folate also called Vitamin B9 is a nutrient found mainly in dark green leafy vegetables and liver, such as spinach, kale, cabbage, spring greens, beans and peas: chickpeas and kidney beans, oranges, lemons, bananas, melons, and strawberries etc.
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